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名称：(R)-2-甲基-4-氧代哌啶-1-羧酸叔丁酯

英文名称：(R)-tert-butyl 2-methyl-4-oxopiperidine-1-carboxylate

分子式：C11H19NO3

分子量: 213.27
Cas No.：790667-43-5
结构式：

规格：97%

用途：基础原料、有机中间体、医药中间体

合成路线如下：

toluene-4-sulfonic acid; acetone;

Reactants are commercially availlable.
Sankyo Company, Limited, EP1375482, A1, (2004) To a solution of 1-t-butoxycarbonyl-2-methyl-4-piperidone ethylene ketal (6.00 g) obtained in reference example 82 in acetone (150 ml) was added p-toluenensulfonic acid monohydrate (4.40 g) with stirr ing under ice-cooling, and the resulting mixture was stirred at room temperature overnight. After stirring, the reaction mixture was diluted with ethyl acetate, and the organic layer was washed succes sively with a saturated sodium hydrogencarbonate solution and a saturated aqueous sodium chloride solution. The organic layer was dried over anhydrous magnesium sulfate and evaporated in vacuo to affo rd the title compound (2.40 g, yield: 48 percent) as a yellow oil. 1H NMR (500MHz, CDCl3) delta ppm : 1.18 (3H, d, J=7.0), 1.49 (9H, s), 2.20-2.30 (1H, m), 2.30-2.40 (1H, m), 2.45-2.55 (1H, m), 2.6 5-2.70 (1H, m), 3.25-3.35 (1H, m), 3.90-4.05 (1H, m), 4.20-4.30 (1H, m).