分子量: 268.28
Cas No.：1187055-62-4
结构式：
规格：97%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
hydrogen; acetic acid; platinum(IV) oxide; 5 rhodium-on-charcoal
Reactants can be synthesized in 1 step.
Tetalman, Michelle, US2010/216839, A1, (2010) To a solution of tert-butyl 5-(trifluoromethyl)pyridin-3-ylcarbamate (3 g, 14 mmol) in glacial acetic acid (50 mL) was added 5percent Rhodium on active carbon (0.5 g) and Platinum(IV) oxide (0.5 g) in the hydrogenation steel bomb. The mixture was sealed and hydrogenated at 200 psi and 70°C. for 48 h. the mixture was filtered through Celite and concentrated to give cis-(+/-)-tert-butyl 5-(trifluor omethyl)piperidin-3-ylcarbamate. LCMS (m/z): 269.1 (MH+).
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