在氨基钠作用下,不能烯醇化的酮在回流的苯或甲苯中发生C-C键断裂,生成羧酸衍生物和羧基被氢取代的分子,这类反应称作Haller-Bauer反应,简称HB反应。
反应机理
反应实例
参考文献
1. Haller, A.;Bauer, E. Compt. Rend. 1908, 147, 824-829.
2. Gilday, J.P.; Gallucci, J. C.; Paquette, L. A. J. Org. Chem. 1989, 54, 1399-1408.
3. Paquette,L. A.; Gilday, J. P.; Maynard, G. D. J. Org. Chem. 1989, 54, 5044-5053.
4. Paquette,L. A.; Gilday, J. P. Org. Prep. Proc. Int. 1990, 22, 167-201.
5. Mehta, G.;Praveen, M. J. Org. Chem. 1995, 60,279-280.
6. Mehta, G.;Venkateswaran, R. V. Tetrahedron 2000, 56, 1399-1422. (Review).
7. Arjona, O.;Medel, R.; Plumet, J. Tetrahedron Lett. 2001, 42,1287-1288.
8. Ishihara,K.; Yano, T. Org. Lett. 2004, 6, 1983-1986.
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