分子量: 138.16
Cas No.：13398-94-2
结构式：
外观：红棕色透明液体
规格：97%
用途：基础原料、有机中间体、医药中间体
合成路线如下：
borane-THF; tetrahydrofuran;
Reactants are commercially availlable.
Sumitomo Pharmaceuticals Company, Limited, EP1386913, A1, (2004) Example 10-1 Preparation for 2-(3-hydroxyphenyl)ethanol To a solution of 3-hydroxyphenylacetic acid (3.04g, 20.0mmol) in tetrahydrofuran (30ml) was added at 0 °C borane-tetrahydrofuran complex (1M, 30.0ml, 30.0mmol) under an atmosphere of n itrogen.. The mixture was stirred for 1 hour, followed by addition of water and the mixture was extracted with ethyl acetate.. The organic layer was dried over magnesium sulfate, filtered and concentrated to give the subject compound (2.76g , 100percent).1H NMR (CDCl3, 400 MHz) delta 7.19 (t, 1 H, J = 7.4 Hz), 6.80 (d, 1 H, J = 7.4 Hz), 6. 72 (s, 1 H), 6. 70 (d, 1 H, J = 7. 4 Hz), 3.86 (t, 2 H, J = 6.5 Hz), 2.83 (t, 2 H, J = 6.5 Hz).
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