外观：黄色固体
用途：基础原料、有机中间体、医药中间体
合成路线如下：
lithium hydroxide; tetrahydrofuran;
Reactants are commercially availlable.
IGNAR, DIANE MICHELE, US2010/113512, A1, (2010) Step 1: 2-Bromo-1,3-thiazole-4-carboxylic Acid A mixture of methyl 2-bromo-1,3-thiazole-4-carboxylat e (4.2 g, 18.9 mmol), THF (120 mL) and 1N lithium hydroxide (50 mL) was heated at 70°C. for 1 h. Th e organic solvent was removed in vacuo. The residual aqueous solution was cooled to 0-5°C. and acid ified to pH1 with 1N HCl solution. The tile compound was obtained by filtration, as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 8.43 (s, 1H) 13.30 (s, 1H).
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