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别名：3,6-二氢-2H-噻喃-4-硼酸频哪醇酯
英文名称：3,6-Dihydrothiopyran-4-Boronic Acid Pinacol Ester
分子式：C11H19BO2S
Cas No.：862129-81-5
分子量：226.14
结构式：

规格：95%

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

sulfur; triethylamine; N,N-dimethyl-formamide; N,N-dimethyl-formamide;

Reactants are commercially availlable.
RAMOT AT TEL-AVIV UNIVERSITY LTD, WO2008/50341, A2, (2008) For a general synthesis see He, X.; Griesser, U. J.; Stowell, J. G.; Borchrdt, T. B.; Byrn, S. R. J. Pharm. Sci. 2001, 90, 371.A Sulfur (S8, 0.9 g, 0.0 27 mmol), propionalaldehyde (2 ml, 0.027 mmol) and DMF (6 ml) were transferred to a thre e-necked round-bottomed flask equipped with a dropping funnel and condenser. The resulting mixture was cooled to 0°C, and EPO triethylamine (2.3 ml) was added in a dropwise manner via the dropping funnel. The resulting dark sol ution was then warmed to room temperature over a period of 1 h. A solution of malononitrile (1.71 ml, 1.8 g, 0.027 mmol) in DMF (3.2 ml) was transferred to the addition funnel and added in a dropwise manner. The resulting brownish mixture w as stirred overnight at room temperature. Then the mixture was poured over 80 ml of ice and water to yield an orange precipitate. The solid A was filtered, washed with chilled water, and dried in vacuo; yield 78percent.1H NMR (200 MHz, CDCl 3): delta 6.35 (s, IH), 4.15 (br s, 2H), 2.27 (s, 3H). 13C NMR (50 MHz, CDCl3): delta 160.9, 146.3, 124.6, 122.0, 115.7, 14.9.