规格：95%
用途：基础原料、有机中间体、医药中间体
合成工艺如下：
phosphoryl chloride;
Reactants are commercially availlable.
Qiu, Jian, US9138427, B2, (2015) Synthesis of Compound 11-2 (0399) Compound 11-1 (5.0 g, 2.86 mmol) was added portionwise to POCl3 ( 15 mL) at 0°C. during 10 min. The reaction mixture was stirred at 120°C. for 4 h, then cooled to r oom temperature and added to ice-water (100 mL). Sat. Na2CO3 was added to adjust pH=7 and extracted with ethyl acetate (200 mL?4). The combined organic layers were dried over Na2SO4, filtered and conc entrated to afford 11-2, which was used in the next step without further purification (4.50 g, 80percent).
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