名称：2-氨基-5-溴-4-甲基噻唑
英文名称：2-Amino-5-bromo-4-methylthiazole
分子式：C4H5BrN2S

分子量: 193.0649
Cas No.：3034-57-9
结构式：

规格：95%

外观：棕色固体

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

bromine; sodium hydrogencarbonate; chloroform; water;

Reactants are commercially availlable.
Institut de Recherches Chimiques et Biologiques Appliquees (I.R.C.E.B.A.), US5322846, A1, (1994) Step 1: Synthesis of 2-amino-5-bromo-4-methylthiazole A solution of bromine in chloroform, consisting of 66.7 ml (1.30 mol) of Br2 in 1000 ml of CHCl3, is added dropwise to a solution of 120 g (1.05 m ol) of 2-amino-4-methylthiazole in 2300 ml of CHCl3, with stirring. A precipitate appears during the addition. Stirring is maintained for 48 h. The reaction medium is then filtered and the hydrobromid e is washed with methylene chloride and then with pentane. The hydrobromide is dissolved in 2000 ml of water and then rendered basic by the addition of 850 ml of a 10percent aqueous solution of sodium bicarbonate. This solution is then extracted with methylene chloride. The organic phase is dried over sodium sulfate. A crystalline residue is obtained after removal of the solvent under vacuum. Brow n crystals: m=155 g (crude yield: 76percent) M.p.KB =112°-113°C . 1 H NMR (delta ppm, DMSO) 2.05 (s, 3H, CH3); 7.15 (s, 2H, NH2).