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名称：2-甲基-4-羟甲基噻唑

英文名称：(2-METHYL-1,3-THIAZOL-4-YL)METHANOL
分子式：C5H7NOS

分子量: 129.18018
Cas No.：76632-23-0
结构式：

外观：黄色液体

规格：95%

用途：基础原料、有机中间体、医药中间体

合成路线如下：

lithium aluminium tetrahydride; tetrahydrofuran; diethyl ether;

Reactants are commercially availlable.
NOVARTIS PHARMA GmbH, WO2005/77932, A2, (2005) 2-Methyl-thiazole-4-carboxylic acid ethyl ester (966 mg, 5.64 mmol) is dissolved in 5 mi of diethylether and cooled to-78°C. A 1 M solution of lithium aluminium hydride in THF (16.9 ml, 16.9 mmol) is added dropwise and the mixture is sirred for 3.5h at-78°C. The mixture is quenched at this temperature with a saturated solution of sodium sulphate and is allowed to warm up to room temperature, followed by extraction with ether and evaporation. Yield : 670 mg (92percent). MS (ES I) : 130.0 [M-H]-, 1H-NMR (CDC13) : b (ppm) 7.20 (s, 1H), 5.27 (dd, 1H), 4.50 (d, 2H), 2.62 (s, 3H).