别名：6-羟基己酸叔丁酯
英文名称：tert-Butyl 6-Hydroxyhexanoate
分子式：C10H20O3
Cas No.：73839-20-0
结构式：

规格：95%

外观：无色液体

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

potassium tert-butylate; dichloromethane;

Reactants are commercially availlable.
KUNZ, Arthur, WO2015/187596, A2, (2015) To a 250 mL round bottom flask equipped with a magnetic stirrer, thermocouple, condenser and nitrogen inlet was charged 6-hexanolactone 14 (3.7 g; 32 mmol) and i-BuOH (100 mL) in DCM followed by i-BuO K (3.9 g; 35 mmol; 1.1 equiv.). This solution was stirred and heated to reflux for 3 hours. The solution was diluted with toluene, washed with water and brine, dried over Na2S04, filtered and concentr ated to afford 4.8 g (80percent yield) as a clear yellow oil. 1H-NMR (500 MHz, CDC13): delta 3.65 - 3.62 (m, 2H), 2.32 - 2.29 (m, 1H), 2.23 - 2.20 (m, 2H), 1.66 - 1.55 (m, 4H), 1.43 (s, 9H), 1.41 - 1. 35 (m, 2H).