新闻

别名：噻唑-4-羧酸乙酯
英文名称：ETHYL THIAZOLE-4-CARBOXYLATE
分子式：C6H7NO2S
Cas No.：14527-43-6
分子量：157.19
结构式：

规格：95%

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

sulfuric acid;

Reactants are commercially availlable.
ATHEROGENICS, INC., WO2008/130718, A1, (2008) Ex. 19c.; To 2-mercaptothiazole-4-carboxylic acid (Ex. 19b, 4.2 g) in 50 mL ethyl alcohol was added 2 mL cone. H2SO4. The mixture was heated to reflux for 8 h and cooled. The solvent was removed unde r reduced pressure and the residue was poured onto 50 mL ice water. The solid was collected, washed with water and dried under vacuum. The crude product was recrystallized from 8 mL ethyl alcohol to a fford ethyl 2-mercaptothiazole-4- carboxylate (2.3 g) as a yellow solid.