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名称：2-碘-5-氯吡啶

英文名称：5-CHLORO-2-IODOPYRIDINE
分子式：C5H3ClIN

分子量: 239.44
Cas No.：244221-57-6
结构式：

外观：黄色固体

规格：96%

用途：基础原料、有机中间体、医药中间体

合成路线如下：

sodium iodide; acetonitrile;

Reactants are commercially availlable.
Ollis, Kristin P., US2003/45546, A1, (2003) a) 5-Chloro-2-iodo-pyridine To a refluxing solution of 2,5-dichloro-pyridine (12.2 g, 82.2 mmol), sodium iodide (37.0 g, 247 mmol) and acetonitrile (170 mL) under argon was added acetyl chloride (9. 0 mL, 127 mmol) and the solution was refluxed for 5 h. To the solution was added more sodium iodide (24.9 g, 166 mmol) and the solution was refluxed for 16 h. More sodium iodide (12.5 g, 83.6 mmol) wa s added and the solution was refluxed for 4.5 h. The solution was cooled to room temperature, and was partitioned between 10percent sodium thiosulfate/10percent aqueous sodium carbonate (300 mL) and e ther (400 mL). The ether layer was washed with brine (100 mL) and dried over anhydrous sodium sulfate. The solution was decanted, and dried in vacuo to yield 16.8 g (85percent) of the title compound a s a brown solid. 1H NMR (CDCl3): 8.36 (d, J=2.75 Hz, 1H), 7.66 (d, J=8.79 Hz, 1H), 7.32 (dd, J=8.38, 2.61 Hz, 1H). There is 5 mol percent of starting material 2,5-dichloro-pyridine in the product as d etermined by NMR.