规格:97%
外观:黄色固体
用途:基础原料、有机中间体、医药中间体
合成路线如下:
sodium sulfide; water; DMFA;
Reactants are commercially availlable.
CHEN, Chixu, WO2011/159839, A2, (2011) [00287] Step C: 3-bromopyridine-2-thiolA mixture of 3-bromo-2-chloropyridine (0.769g, 4mmol) and sod ium sulfide (0.336g, 6mmol) in DMF (3mL) was heated under microwave irradiation at 130°C for 0.5 hou r. Water (50mL) and ethyl acetate (20mL) were added and the layers separated. The aqueous layer was acidified to pH 6 resulting in the formation of a precipitate, which was isolated by filtration and dried under vacuum to yield the product as a yellow solid (0.42g, 55percent).
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