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产品推荐:3-溴-2-巯基吡啶(65938-86-5)

别名:3-溴-2-巯基吡啶
英文名称:3-BroMopyridine-2-thiol
分子式:C5H4BrNS
Cas No.:65938-86-5
分子量:190.06096
结构式:image.png

规格:97%

外观:黄色固体

用途:基础原料、有机中间体、医药中间体

合成路线如下:

sodium sulfide; water; DMFA;

Reactants are commercially availlable.
CHEN, Chixu, WO2011/159839, A2, (2011) [00287] Step C: 3-bromopyridine-2-thiolA mixture of 3-bromo-2-chloropyridine (0.769g, 4mmol) and sod ium sulfide (0.336g, 6mmol) in DMF (3mL) was heated under microwave irradiation at 130°C for 0.5 hou r. Water (50mL) and ethyl acetate (20mL) were added and the layers separated. The aqueous layer was acidified to pH 6 resulting in the formation of a precipitate, which was isolated by filtration and dried under vacuum to yield the product as a yellow solid (0.42g, 55percent).


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