别名：2-溴-4-醛基噻唑
英文名称：2-Bromo-4-fomylthiazole
分子式：C4H2BrNOS
Cas No.：5198-80-1
分子量：192.03
结构式：

别名：2-溴-4-醛基噻唑
英文名称：2-Bromo-4-fomylthiazole
分子式：C4H2BrNOS
Cas No.：5198-80-1
分子量：192.03
结构式：

规格：95%

外观：黄色固体

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

diisobutylaluminium hydride; hydrogenchloride; tetrahydrofuran; hexanes; dichloromethane; tetrahydrofuran; methanol; hexanes; dichloromethane; water;

Reactants are commercially availlable.
GLAXO GROUP LIMITED, WO2007/65669, A1, (2007) Ethyl 2-bromothiazole-4-carboxylate (3g, 12.7mmol) was taken up in THF and dichloromethane (100ml each) and cooled to -780C. 1 M DIBAL-H in hexanes (25.4ml, 25.4mmol) was added dropwise maintaining the temperature at <-70°C. The solution wa s stirred for 5h and quenched with MeOH (20ml). The solution was allowed to warm to room temperature, poured into 1 M HCI (200ml) and extracted with EtOAc (3x100ml). The combined organics were washed with brine (300ml), dried (Na2SO4) and c oncentrated. Purification by column chromatography on silica (0-50percent EtOAc\\40-60 pet. ether gradient) yielded the product as a white solid (0.862g). deltaH (CDCI3) 8.10(1 H, s), 9.95(1 H, s).