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名称：2-甲硫基-4-氯-5-氰基嘧啶

英文名称：4-Chloro-2-(methylthio)pyrimidine-5-carbonitrile

分子式：C6H4ClN3S

分子量: 185.63
Cas No.：33089-15-5
结构式：

规格：95%

用途：基础原料、有机中间体、医药中间体

合成路线如下：

trichlorophosphate;

Reactants are commercially availlable.
Lyle, Terry Alan, US2003/158218, A1, (2003) A mixture of 7.5660 g (45.25 mmol) 4-hydroxy-2-(methylthio)pyrimidine-5-carbonitrile and 40 mL (429. 14 mmol) of phosphorus oxychloride was heated at 110°C. for 3.5 h and then concentrated in vacuo. T o the resulting residue was added and decanted boiling hexane (60 mL*4). The combined hexane fractions were concentrated in vacuo to give of 4-chloro-2-(methylthio)pyrimidine-5-carbonitrile as a yello w solid. 1H NMR (CDCl3, 400 MHz) delta 8.645 (s, 1H, ArH); 2.625 (s, 3H, CH3); MS ES+M+1=186.0