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波普医药正在热销：

别名：溴甲基环丙烷

英文名称：(Bromomethyl)cyclopropane

分子式：C4H7Br

Cas No.：7051-34-5

分子量：135

结构式：

规格：97%

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

bromine; triphenylphosphine; N-methylacetamide;

Reactants are commercially availlable.

Bayer Aktiengesellschaft, US6008420, A1, (1999) Example 1 (for comparison) 1250 ml of dimethylformamide were placed into the reaction vessel, and then 280.8 g of triphenylphosphine and then 70 g of hydroxymethylcyclopropane were added, the mixture was stirred for 30 minutes at room temperature under a nitrogen atmosphere, and the solution was sub sequently cooled to -10°C. Then, 158.3 g of bromine (that is to say 2 mol percent more than theoret ically required) were metered in in the course of 4 hours. The reaction mixture was worked up by distillation. Bromomethylcyclopropane was obtained in a yield of 77.5percent of theory. The purity of the product was over 97percent, the open-chain halogenoalkanes amounted to 0.6percent.