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波普医药正在热销：

别名：4-氯-2-甲基喹啉
英文名称：4-CHLORO-2-METHYLQUINOLINE
分子式：C10H8ClN
Cas No.：4295-06-1
分子量：177.63

结构式：

规格：97%

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

trichlorophosphate;

Reactants are commercially availlable.

Academia Sinica, US2008/171765, A1, (2008) 1) Synthesis of 4-chloro-2-methylquinoline The commercially available 4-hydroxy-2-methylquinoline (6.522 g, 41 mmol) was added portionwise to POCl3 (35 mL) in a round flask at 0°C. with stirring. The homogenous suspension was then immersed into a pre-heated at 80°C. oil bath and continuously refluxed for 4 h. The reaction mixture was cooled to room temperature and the excess POCl3 was distilled out under reduces pressure. The residue was treated carefully with ice (150 g) a nd then with saturated NaHCO3 aqueous solution (200 mL). The mixture was extracted with CH2Cl2 (100*3 mL), dried over Na2SO4, and evaporated in vacuo to dryness to give known 4-chloro-2-methylquinoline,53 6.10 g (84.14percent) as oil, which was pure enough for using in next step. 1H NMR (DMSO) delta 2.61 (3H, s, Me), 7.66 (1H, s, ArH), 7.67-7.71 (1H, m, ArH), 7.82-7.85 (1H, s, ArH), 8.01 (1H, d, J=6.7 Hz, ArH), 8.12-8.14 (1H, s, ArH). Anal. Calcd. for (C10H8ClN): C, 67.62; H, 4.54; N, 7.89. Found: C, 67.62; H, 4.54; N, 7.89.