新闻

别名：5-溴-2-氯嘧啶
英文名称：5-Bromo-2-chloropyrimidine
分子式：C4H2BrClN2
Cas No.：32779-36-5
分子量：193.43
结构式：

规格：95%

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

phosphoryl chloride;

Reactants are commercially availlable.
Qiu, Jian, US9138427, B2, (2015) Synthesis of Compound 11-2 (0399) Compound 11-1 (5.0 g, 2.86 mmol) was added portionwise to POCl3 ( 15 mL) at 0°C. during 10 min. The reaction mixture was stirred at 120°C. for 4 h, then cooled to r oom temperature and added to ice-water (100 mL). Sat. Na2CO3 was added to adjust pH=7 and extracted with ethyl acetate (200 mL?4). The combined organic layers were dried over Na2SO4, filtered and conc entrated to afford 11-2, which was used in the next step without further purification (4.50 g, 80percent).