名称：3-氟吡咯烷盐酸盐
英文名称：3-fluoropyrrolidine,hydrochloride
分子式：C4H8FN.ClH

分子量: 128.20
Cas No.：169750-17-8
结构式：

规格：97%

用途：基础原料、有机中间体、医药中间体

合成工艺如下：

hydrogenchloride; 1,4-dioxane;

Reactants are commercially availlable.
NOVARTIS PHARMA GMBH, WO2004/69256, A1, (2004) To a solution of 3-(R)-HYDROXY-PYRROLIDINE-1-CARBOXYLIC acid ter-butyl ester (200mg) in CH2CI2 (1 OML) is added [bis (2-methoxyethyl) amino] sulfer trifluoride (236uL) at 0C, and stirred for 1HR at ro om temperature. The reaction mixture is poured in aqueous NaHC03 and extracted with Et20. The organic layer is successively washed with H20 and aqueous NACI, dried over MGS04, and concentrated in vacu o. The residue is purified by column chromatography to give a colorless oil. The oil is dissolved in 4N HCI in dioxane (5mL) and stirred for 1. 5hr at room temperature. The reaction mixture is concent rated in vacuoto provide the title compound.